Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Metoclopramide (5-Chloro-2-methoxyprocainamide) 是5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 和 483 nM,可用于恶心呕吐、胃食管反流和胃轻瘫的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 343 | 现货 | ||
100 mg | ¥ 497 | 现货 | ||
500 mg | ¥ 980 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 547 | 现货 |
产品描述 | Metoclopramide (5-Chloro-2-methoxyprocainamide) is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. |
靶点活性 | 5-HT3 receptor:308 nM (IC50), D2 receptor:483 nM (IC50) |
别名 | 甲氧氯普胺, 胃复安, 5-Chloro-2-methoxyprocainamide |
分子量 | 299.8 |
分子式 | C14H22ClN3O2 |
CAS No. | 364-62-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (183.46 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3356 mL | 16.6778 mL | 33.3556 mL | 83.3889 mL |
5 mM | 0.6671 mL | 3.3356 mL | 6.6711 mL | 16.6778 mL | |
10 mM | 0.3336 mL | 1.6678 mL | 3.3356 mL | 8.3389 mL | |
20 mM | 0.1668 mL | 0.8339 mL | 1.6678 mL | 4.1694 mL | |
50 mM | 0.0667 mL | 0.3336 mL | 0.6671 mL | 1.6678 mL | |
100 mM | 0.0334 mL | 0.1668 mL | 0.3336 mL | 0.8339 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Metoclopramide 364-62-5 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor gastro-oesophageal inhibit Serotonin Receptor 5-hydroxytryptamine Receptor 甲氧氯普胺 胃复安 5-Chloro-2-methoxyprocainamide gastroparesis Inhibitor nausea reflux vomiting inhibitor