store at low temperture,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Melittin Acetate (Forapin Acetate) 是一种PLA2激活剂。Melittin Acetate 低分子量 PLA2 的活性具有刺激,而不会增加高分子量 PLA2 的活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 673 | 现货 | ||
5 mg | ¥ 1,310 | 现货 | ||
10 mg | ¥ 2,290 | 现货 | ||
25 mg | ¥ 3,890 | 现货 | ||
50 mg | ¥ 5,560 | 现货 | ||
100 mg | ¥ 7,790 | 现货 | ||
500 mg | ¥ 15,500 | 现货 |
产品描述 | Melittin Acetate (Forapin Acetate) is a PLA2 activator. Melittin Acetate stimulates the activity of the low molecular weight PLA2, while it does not increase the activity of the high molecular weight PLA2. |
体外活性 | Melittin Acetate is an immunologically related PLA2 stimulating peptide from bee venom. Melittin Acetate increases the activity of the high molecular weight enzyme[1]. Melittin Acetate is a cytotoxic peptide from bee venom. Melittin Acetate shows toxicity against both A2780CR and A2780 cells, with IC50 values of 4.5 and 6.8 μg/mL, respectively. Melittin Acetate shows natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also been shown to have diverse anticancer effects in several different cancer cell lines including those of gastric, breast, ovarian, liver, prostate, cervical, and lung origins. The mechanisms by which Melittin Acetate, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. Melittin Acetate can also prevent EGF-induced cell invasion through its inhibition of the PI3K/Akt/mTOR signaling pathway, but this is primarily related to breast cancer cells[2]. |
别名 | Melittin Acetate(20449-79-0 Free base), Forapin Acetate |
分子量 | 2906.51 |
分子式 | C133H233N39O33 |
store at low temperture,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Melittin Acetate Metabolism Phospholipase Melittin Acetate(20449-79-0 Free base) Forapin Acetate Inhibitor inhibitor inhibit