Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MCT1-IN-3是一种单羧酸转运蛋白1 (MCT1)抑制剂。溶质载体(SLC)单羧酸转运蛋白1 (MCT1);SLC16A1)是治疗癌症的一个有希望的靶点。MCT1-IN-3(化合物24)对MCT1转运抑制作用强,IC50值为81.0 nM。MCT1-IN-3对多药转运体ABCB1也有明显的抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,290 | 现货 | ||
5 mg | ¥ 2,990 | 现货 | ||
10 mg | ¥ 4,390 | 现货 | ||
25 mg | ¥ 6,910 | 现货 | ||
50 mg | ¥ 9,480 | 现货 | ||
100 mg | ¥ 12,800 | 现货 | ||
500 mg | ¥ 25,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,990 | 现货 |
产品描述 | MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor. The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. |
靶点活性 | MCT1:81nM |
体外活性 | MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI50 values of 20 μM and 15.1 μM, respectively. Treatment with MCT1-IN-3 5μM for 24 h significantly leads to cancer cell cycle arrest as well as apoptosis, which has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR)[1]. |
分子量 | 389.4 |
分子式 | C22H19N3O4 |
CAS No. | 2878360-80-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (57.78 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5681 mL | 12.8403 mL | 25.6805 mL | 64.2013 mL |
5 mM | 0.5136 mL | 2.5681 mL | 5.1361 mL | 12.8403 mL | |
10 mM | 0.2568 mL | 1.284 mL | 2.5681 mL | 6.4201 mL | |
20 mM | 0.1284 mL | 0.642 mL | 1.284 mL | 3.2101 mL | |
50 mM | 0.0514 mL | 0.2568 mL | 0.5136 mL | 1.284 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MCT1-IN-3 2878360-80-4 Membrane transporter/Ion channel Monocarboxylate transporter MCT1IN3 Inhibitor inhibitor inhibit