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Latanoprost

Latanoprost

产品编号 T2528   CAS 130209-82-4
别名: Xalatan, PHXA41, 拉坦前列腺素, 拉坦前列素

Latanoprost (Xalatan) 是前列腺素 F2α 类似物,是一种前列腺素受体激动剂,能够降低眼内压。

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Latanoprost Chemical Structure
Latanoprost, CAS 130209-82-4
规格 价格/CNY 货期 数量
1 mg ¥ 319 现货
2 mg ¥ 453 现货
5 mg ¥ 788 现货
10 mg ¥ 1,450 现货
25 mg ¥ 2,890 现货
50 mg ¥ 4,330 现货
100 mg ¥ 6,170 现货
500 mg ¥ 12,600 现货
1 mL * 10 mM (in DMSO) ¥ 867 现货
其他形式的 Latanoprost:
产品目录号及名称: Latanoprost (T2528)
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纯度: 99.78%
纯度: 99.76%
纯度: 99.69%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect.
体外活性 Latanoprost functioned as both an indirect activator of AMP-activated protein kinase and a selective retinoid X receptor α (RXRα) antagonist able to selectively antagonise the transcription of a RXRα/peroxisome proliferator-activated receptor γ heterodimer[2]. Latanoprost induced morphological abnormality and viability decline of HCS cells in vitro. It induces cell cycle arrest of HCS cells. Latanoprost induces abnormal changes of plasma membrane, DNA fragmentation and ultrastructural abnormality of HCS cells. Caspase activation in HCS cells is also activated by Latanoprost treatment. Latanoprost induces MTP disruption and quantitative changes of mitochondrion-associated pro-apoptotic regulators in HCS cells[1]. Latanoprost is effective in inhibiting adipogenesis, reducing lipogenesis, promoting fatty acid oxidation and enhancing GLUT4 translocation and glucose uptake both in adipocytes and myotubes[2].
体内活性 Latanoprost, a clinical drug for treating primary open-angle glaucoma and intraocular hypertension, effectively ameliorates glucose and lipid disorders in two mouse models of type 2 diabetes. Its treatment improves glucose tolerance. Chronic administration of latanoprost decreases serum lipids and enhances insulin signalling in white adipose tissue and skeletal muscle. It effectually activates AMPK and regulates glucose and lipid metabolism-relevant genes in diabetic mice[2].
细胞实验 HCS cells were inoculated into a 24-well culture plate (Nunc) and cultured in 10% FBS-DMEM/F12 medium at 37°C in a humidified 5% CO2 incubator. After the cells grew into logarithmic phase, the culture medium of each culture plate well was replaced entirely with the medium containing latanoprost at concentrations varying from 50 mg/l to 0.78125 mg/l, respectively. The cells were cultured under the same condition as described earlier, and their morphology and growth status were monitored every 4 h under an Eclipse TS100 inverted microscope.(Only for Reference)
别名 Xalatan, PHXA41, 拉坦前列腺素, 拉坦前列素
分子量 432.59
分子式 C26H40O5
CAS No. 130209-82-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 4.33 mg/mL (10 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3117 mL 11.5583 mL 23.1166 mL 57.7914 mL
5 mM 0.4623 mL 2.3117 mL 4.6233 mL 11.5583 mL
10 mM 0.2312 mL 1.1558 mL 2.3117 mL 5.7791 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Shen JW, et al. Curr Eye Res. 2016, 17:1-8. 2. Wang G, et al. Diabetologia. 2013, 56(12):2702-12. 3. Richard L. Hébert, et al. The journal of biological chemistry.

文献引用

1. Wu S, Liu C, Tang J, et al.Tafluprost promotes axon regeneration after optic nerve crush via Zn2+-mTOR pathway.Neuropharmacology.2023: 109746.
IBC 293 Tyrphostin A25 1-methoxycyclopropanecarboxylic acid Ginsenoside Rb2 AF64394 2-(pentylsulfanyl)pyrimidine-4,6-diol MK-6892 RTI-13951-33

相关化合物库

该产品包含在如下化合物库中:
抗癌药物库 抗癌上市药物库 抗癌临床化合物库 药物功能重定位化合物库 经典已知活性库 脂代谢化合物库 抗衰老化合物库 GPCR靶点分子库 氧化还原化合物库 上市药物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Latanoprost 130209-82-4 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Metabolism GPR Prostaglandin Receptor RAR/RXR  Xalatan PHXA41 拉坦前列腺素 PHXA 41 Inhibitor 拉坦前列素 PHXA-41 inhibit inhibitor

 

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