Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Laminaran 是一种从褐藻中分离出来的 β-1-3-葡聚糖,常作为 Dectin-1 的典型配体,具有抗癌、免疫调节和辐射防护作用。 Laminaran 可被葡糖酶催化。Laminaran 在体内外实验中显示出抗肿瘤活性,可用于预防和治疗癌症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 289 | 现货 | ||
100 mg | ¥ 412 | 现货 | ||
500 mg | ¥ 978 | 现货 |
产品描述 | Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers. |
体外活性 |
Laminarin ( 100-800μg / mL ; 24 h ) had no cytotoxicity to normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28. After 15 hours of treatment, the inhibition percentage of the number of living cells was less than 24 % when the concentration was up to 800μg / mL [ 1 ]. Kelp glycan ( 200μg / mL ; 24-72 hours ) did not induce any growth inhibition of SK-MEL-48 cells after treatment for 28 hours and 24 hours. However, it reduced cell proliferation by 72 % after 36 hours of treatment [ 1 ]. Low concentration of kelp glycan ( 25-50μg / mL ; 24 h ) did not affect the phosphorylation of c-Raf ( Ser259 ), ERK1 / 2 ( Tyr202 / Tyr204 ) and MEK1 / 2 ( Ser 221 ) kinases, as well as the total expression level of the studied proteins. However, it reduced p-MEK and p-ERK2 / 50 at 1 μg / mL [ 1 ]. |
体内活性 | 与PBS-、OVA-和海带蛋白处理的小鼠相比,Laminaran(静脉注射;12.5、25及50 mg/kg;21天)与OVA(50μg)联合使用显著减少了肿瘤质量[2]。 |
别名 | β-1,3-Glucan |
分子量 | 521.469 |
分子式 | C18H35NO16 |
CAS No. | 9008-22-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 15 mg/mL, Sonication is recommended.
DMSO: < 1mg/ml (insoluble), Sonication is recommended.
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Laminaran 9008-22-4 β-1,3-Glucan b-1,3-Glucan beta-1,3-Glucan Inhibitor inhibitor inhibit