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L48H37

产品编号 T40423 CAS 343307-76-6

L48H37是Curcumin的一个化学稳定类似物。它对髓系分化蛋白2 (MD2) 表现出强效的抑制性质，作为一个特异性抑制剂。其机制包括抑制LPS-TLR4/MD2的相互作用和信号传导。L48H37主要用于脓血症和肺损伤研究[1]。

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L48H37, CAS 343307-76-6

规格	价格/CNY	货期
1 mg	￥ 283	现货
2 mg	￥ 395	现货
5 mg	￥ 638	现货
10 mg	￥ 927	现货
25 mg	￥ 1,970	现货
50 mg	￥ 3,130	现货
100 mg	￥ 4,590	现货
500 mg	￥ 9,870	现货
1 mL * 10 mM (in DMSO)	￥ 731	现货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is primarily utilized in sepsis and lung injury research [1].
体外活性	L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages [1] .L48H37 (0-20 μM; 24 hours) decreases the viability of A549 and H460 cells with IC 50 values of 5.3 μM and 2.3 μM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC 50 of 21 μM [2] .L48H37 (1, 2, or 4 μM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells [2] .L48H37 (4 μM; 16 hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells [2] . Cell Viability Assay [2] Cell Line: A549 and H460 cells; BEAS-2B cells Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20?μM Incubation Time: 24 hours Result: Inhibited lung cancer cells growth in a concentration-dependent manner. Western Blot Analysis [2] Cell Line: A549 and H460 cells Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20?μM Incubation Time: 24 hours Result: Decreased p‐Cdc2, Cdc2, and Bcl‐2 expression in 2 lung cancer cells.
体内活性	L48H37 (intraperitoneal injection; 5 mg or 10 mg/kg; once daily; 11‐day) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice [1] . Animal Model: 5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g) [2] Dosage: 5 mg or 10 mg/kg Administration: Intraperitoneal injection; once daily; 11‐day Result: Reduced tumor wet weights as compared to vehicle control. Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo.Exhibited no significant structural changes in mice.

分子量	483.55
分子式	C27H33NO7
CAS No.	343307-76-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 45 mg/mL (93.06 mM), Sonication is recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.068 mL	10.3402 mL	20.6804 mL	51.701 mL
	5 mM	0.4136 mL	2.068 mL	4.1361 mL	10.3402 mL
	10 mM	0.2068 mL	1.034 mL	2.068 mL	5.1701 mL
	20 mM	0.1034 mL	0.517 mL	1.034 mL	2.585 mL
	50 mM	0.0414 mL	0.2068 mL	0.4136 mL	1.034 mL

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参考文献

1. Yi Wang, et al. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50 2. Chen Feng, et al. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56(7):1765-1777.

剂量换算

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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