Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IXA4 是一种高选择性、无毒的 IRE1/XBP1s 激活剂,通过激活 IRE1 来减少 APP 的分泌。它刺激的 IRE1 激活也增强了胰腺功能。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 295 | 现货 | ||
5 mg | ¥ 453 | 现货 | ||
10 mg | ¥ 787 | 现货 | ||
25 mg | ¥ 1,680 | 现货 | ||
50 mg | ¥ 2,720 | 现货 | ||
100 mg | ¥ 3,970 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 490 | 现货 |
产品描述 | IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function. |
体外活性 | In other cell lines including Huh7 and SHSY5Y cells, IXA4 selectively upregulated XBP1s mRNA relative to genes regulated by ATF6 (eg BiP) or PERK (eg CHOP). IXA4 reduces Aβ levels by 50% in conditioned medium prepared on CHO7PA2 cells expressing the V717F APP (APPV717F) mutant [1]. IXA4 rescues mitochondrial defects in SH-SY5Y cells expressing disease-associated APP mutants. After 4 h of treatment in HEK293T cells, IXA4 promotes adaptive IRE1/XBP1s signaling, but not RIDD [1]. IXA4 also promotes selective transcriptional remodeling of the ER proteostasis pathway relative to the cytoplasmic or mitochondrial pathway [1]. |
分子量 | 436.5 |
分子式 | C24H28N4O4 |
CAS No. | 1185329-96-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (187.857 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.291 mL | 11.4548 mL | 22.9095 mL | 57.2738 mL |
5 mM | 0.4582 mL | 2.291 mL | 4.5819 mL | 11.4548 mL | |
10 mM | 0.2291 mL | 1.1455 mL | 2.291 mL | 5.7274 mL | |
20 mM | 0.1145 mL | 0.5727 mL | 1.1455 mL | 2.8637 mL | |
50 mM | 0.0458 mL | 0.2291 mL | 0.4582 mL | 1.1455 mL | |
100 mM | 0.0229 mL | 0.1145 mL | 0.2291 mL | 0.5727 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IXA4 1185329-96-7 Cell Cycle/Checkpoint IRE1 endoplasmic reticulum (ER) proteostasis UPR protein secretion Inhibitor Inositol requiring enzyme 1 IXA 4 unfolded protein response IXA-4 inhibit inhibitor