Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸,具有潜在的抗肿瘤活性。 它结合并激活核视黄酸受体 (RAR), 活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物,用于治疗严重的痤疮和某些形式的皮肤、头颈癌。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 243 | 现货 | ||
100 mg | ¥ 333 | 现货 | ||
500 mg | ¥ 882 | 现货 |
产品描述 | Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturally-occurring retinoic acid with potential antineoplastic activity. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. |
体外活性 | Isotretinoin 直接干扰颅神经嵴细胞的发育。[1] Isotretinoin 通过减少神经嵴细胞与细胞基质的黏附力,选择性地影响神经嵴细胞。[2] |
体内活性 | Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. [1] Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. [3] Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. [4] Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. [5] |
别名 | 13-cis-Retinoic acid, 异维A酸 |
分子量 | 300.44 |
分子式 | C20H28O2 |
CAS No. | 4759-48-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1 mg/mL (3.32 mM), Heating is recommended.
DMSO: 45 mg/mL (149.78 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 3.3285 mL | 16.6423 mL | 33.2845 mL | 83.2113 mL |
DMSO | 5 mM | 0.6657 mL | 3.3285 mL | 6.6569 mL | 16.6423 mL |
10 mM | 0.3328 mL | 1.6642 mL | 3.3285 mL | 8.3211 mL | |
20 mM | 0.1664 mL | 0.8321 mL | 1.6642 mL | 4.1606 mL | |
50 mM | 0.0666 mL | 0.3328 mL | 0.6657 mL | 1.6642 mL | |
100 mM | 0.0333 mL | 0.1664 mL | 0.3328 mL | 0.8321 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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