Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isocarboxazid 是不可逆的、非选择性的单胺氧化酶 monoamine oxidase 抑制剂,其在大鼠大脑中测得的 IC50值为4.8 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 239 | 现货 | ||
2 mg | ¥ 346 | 现货 | ||
5 mg | ¥ 579 | 现货 | ||
10 mg | ¥ 849 | 现货 | ||
25 mg | ¥ 1,420 | 现货 | ||
50 mg | ¥ 2,090 | 现货 | ||
100 mg | ¥ 3,150 | 现货 | ||
500 mg | ¥ 6,990 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 637 | 现货 |
产品描述 | Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor.[2] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. |
靶点活性 | Monoamine oxidase (rat brain):4.8 μM |
体外活性 | In vivo studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.[1] |
体内活性 | In vitro studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.[1] |
分子量 | 231.25 |
分子式 | C12H13N3O2 |
CAS No. | 59-63-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (216.22 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.3243 mL | 21.6216 mL | 43.2432 mL | 108.1081 mL |
5 mM | 0.8649 mL | 4.3243 mL | 8.6486 mL | 21.6216 mL | |
10 mM | 0.4324 mL | 2.1622 mL | 4.3243 mL | 10.8108 mL | |
20 mM | 0.2162 mL | 1.0811 mL | 2.1622 mL | 5.4054 mL | |
50 mM | 0.0865 mL | 0.4324 mL | 0.8649 mL | 2.1622 mL | |
100 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL | 1.0811 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Isocarboxazid 59-63-2 Neuroscience Monoamine Oxidase inhibit MAO Inhibitor inhibitor