Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isavuconazonium sulfate 是一种口服活性抗真菌药,是活性三唑类抗真菌药物 Isavuconazole 的前药,可用于侵袭性曲霉菌病和毛霉菌病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 295 | 现货 | ||
5 mg | ¥ 690 | 现货 | ||
10 mg | ¥ 1,080 | 现货 | ||
25 mg | ¥ 1,960 | 现货 | ||
50 mg | ¥ 2,970 | 现货 | ||
100 mg | ¥ 4,320 | 现货 | ||
500 mg | ¥ 8,900 | 现货 |
产品描述 | Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield ergosterol, an important component of the fungal cell membrane. Isavuconazonium Sulfate is a prodrug of the triazole antifungal agent isavuconazole, with broad-spectrum antifungal activity. Inhibition of CYP51 leads to a decrease in fungal ergosterol production and disrupts the synthesis of the fungal cell membrane, which decreases membrane integrity, increases cell membrane permeability and promotes the loss of essential intracellular elements. This results in fungal cell lysis and death. |
分子量 | 814.84 |
分子式 | C35H36F2N8O9S2 |
CAS No. | 946075-13-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (61.36 mM)
H2O: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.2272 mL | 6.1362 mL | 12.2723 mL | 30.6809 mL |
5 mM | 0.2454 mL | 1.2272 mL | 2.4545 mL | 6.1362 mL | |
10 mM | 0.1227 mL | 0.6136 mL | 1.2272 mL | 3.0681 mL | |
20 mM | 0.0614 mL | 0.3068 mL | 0.6136 mL | 1.534 mL | |
50 mM | 0.0245 mL | 0.1227 mL | 0.2454 mL | 0.6136 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Isavuconazonium sulfate 946075-13-4 Microbiology/Virology Antifungal inhibit antifungal prodrug aspergillosis BAL8557-002 Fungal mucormycosis invasive Isavuconazonium Isavuconazonium Sulfate Inhibitor infections inhibitor