Powder: -20°C for 3 years | In solvent: -80°C for 1 year
INE963 是快速有效的血液阶段抗疟剂,EC50为 3-6 nM。INE963 有单纯性疟疾的研究潜力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 561 | 现货 | ||
5 mg | ¥ 1,390 | 现货 | ||
10 mg | ¥ 2,150 | 现货 | ||
25 mg | ¥ 3,650 | 现货 | ||
50 mg | ¥ 5,260 | 现货 | ||
100 mg | ¥ 7,430 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,590 | 现货 |
产品描述 | INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P. vivax clinical isolates from Brazil and Uganda with EC50’s ranging from 0.01 to 7.0 nM |
靶点活性 | Pf3D7:6 nM(EC50) |
体外活性 | INE963 is active against >15 drug-resistant Pf cell lines with EC50’s = 0.5–15 nM. The in vitro log parasite reduction ratio for INE963 is >8.0 at 10 × Pf 3D7 EC50 without a lag phase and a parasite clearance time (PCT99.9) of <24 h. The in vitro selectivity of INE963for Plasmodium vs human cells was exemplified by approximately 1000+ fold shifts against multiple human kinase biochemical assays[1]. |
体内活性 | Following four oral doses at 30 mg/kg of INE963, the frontrunner compounds tested showed significant parasitemia reduction (>99.9%) at day 5 compared to untreated control mice. In addition, the animals did not show any signs of recrudescence of parasite at day 60 post-treatment, indicating complete cure at these doses[1]. |
分子量 | 402.51 |
分子式 | C19H26N6O2S |
CAS No. | 2640567-43-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (124.22 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4844 mL | 12.4221 mL | 24.8441 mL | 62.1103 mL |
5 mM | 0.4969 mL | 2.4844 mL | 4.9688 mL | 12.4221 mL | |
10 mM | 0.2484 mL | 1.2422 mL | 2.4844 mL | 6.211 mL | |
20 mM | 0.1242 mL | 0.6211 mL | 1.2422 mL | 3.1055 mL | |
50 mM | 0.0497 mL | 0.2484 mL | 0.4969 mL | 1.2422 mL | |
100 mM | 0.0248 mL | 0.1242 mL | 0.2484 mL | 0.6211 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
INE963 2640567-43-5 Others uncomplicated malaria inhibit INE 963 Parasite antimalarial INE-963 Inhibitor inhibitor