Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IKarisoside A(Baohuoside II) 是一种来自小檗科植物淫羊藿的黄酮醇糖苷,具有抗炎活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 422 | 现货 | ||
5 mg | ¥ 1,980 | 现货 | ||
10 mg | ¥ 2,970 | 现货 | ||
25 mg | ¥ 4,900 | 现货 | ||
50 mg | ¥ 6,890 | 现货 |
产品描述 | IKarisoside A(Baohuoside II) is a flavonol glycoside from the Berberidaceae plant Epimedium, with anti-inflammatory activity. |
体外活性 | Ikarisoside A is a natural flavonol glycoside derived from plants of the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. We found that Ikarisoside A (1-100 μM) concentration-dependently inhibited the secretion of catecholamines induced by acetylcholine, a physiological secretagogue and agonist of nicotinic acetylcholine receptors. Ikarisoside A had little effect on catecholamine secretion induced by veratridine and 56 mM K(+). Ikarisoside A (1-100 μM) also inhibited (22)Na(+) influx and (45)Ca(2+) influx induced by acetylcholine in a concentration-dependent manner similar to that of catecholamine secretion. In Xenopus oocytes expressing α3β4 nicotinic acetylcholine receptors, Ikarisoside A (0.1-100 μM) directly inhibited the current evoked by acetylcholine. It also suppressed (14)C-catecholamine synthesis and tyrosine hydroxylase activity induced by acetylcholine at 1-100 μM and 10-100 μM, respectively. The present findings suggest that Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppression of nicotinic acetylcholine receptor-ion channels in bovine adrenal medullary cells.[1] |
别名 | Icarisoside-, Baohuoside II |
分子量 | 500.49 |
分子式 | C26H28O10 |
CAS No. | 55395-07-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/ml(228 mM)
Ethanol: 1 mg/ml(1.77 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 1.998 mL | 9.9902 mL | 19.9804 mL | 49.951 mL |
DMSO | 5 mM | 0.3996 mL | 1.998 mL | 3.9961 mL | 9.9902 mL |
10 mM | 0.1998 mL | 0.999 mL | 1.998 mL | 4.9951 mL | |
20 mM | 0.0999 mL | 0.4995 mL | 0.999 mL | 2.4976 mL | |
50 mM | 0.04 mL | 0.1998 mL | 0.3996 mL | 0.999 mL | |
100 mM | 0.02 mL | 0.0999 mL | 0.1998 mL | 0.4995 mL |
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
川滇淫羊藿 | Epimedium davidii Franch.(Epimedium memberanaceum K Meyer) | 温 | 甘, 微苦 |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IKarisoside A 55395-07-8 Immunology/Inflammation NO Synthase Icarisoside- Baohuoside II Inhibitor inhibitor inhibit