Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Helichrysetin 是从豆蔻果实中分离出的一种天然产物,是一种 DNA 结合抑制剂,可抑制原位导管癌DCIS 的形成。它抑制细胞生长,可诱导 A549 细胞凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,190 | 现货 | ||
5 mg | ¥ 2,570 | 现货 | ||
10 mg | ¥ 3,790 | 现货 | ||
25 mg | ¥ 5,900 | 现货 | ||
50 mg | ¥ 8,120 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,420 | 现货 |
产品描述 | Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29. |
体外活性 | Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C (1) and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes. The known compounds were identified to be panduratin A (2), hydroxypanduratin A (3), Helichrysetin (4), 2',4',6'-trihydroxyhydrochalcone (5), and uvangoletin (6). The structures of all compounds were elucidated on the basis of chemical and spectroscopic methods. It was found that 3 possessed the most potent anti-HIV-1 PR activity with an IC50 value of 5.6 microM, followed by 2 (IC50 = 18.7 microM), whereas other compounds exhibited only mild activity. |
别名 | 4,2',4'-三羟基-6'-甲氧基查耳酮, 蜡菊亭 |
分子量 | 286.28 |
分子式 | C16H14O5 |
CAS No. | 62014-87-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (78.59 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4931 mL | 17.4654 mL | 34.9308 mL | 87.3271 mL |
5 mM | 0.6986 mL | 3.4931 mL | 6.9862 mL | 17.4654 mL | |
10 mM | 0.3493 mL | 1.7465 mL | 3.4931 mL | 8.7327 mL | |
20 mM | 0.1747 mL | 0.8733 mL | 1.7465 mL | 4.3664 mL | |
50 mM | 0.0699 mL | 0.3493 mL | 0.6986 mL | 1.7465 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Helichrysetin 62014-87-3 Apoptosis Microbiology/Virology Proteases/Proteasome HIV Protease Inhibitor 4,2',4'-三羟基-6'-甲氧基查耳酮 growth DCIS inhibit cell cycle 蜡菊亭 ID2 anticancer inhibitor