Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC6-IN-11 (Compound 9) 对癌细胞具有抗增殖活性。HDAC6-IN-11 是 HDAC6 的选择性抑制剂,IC50值为 20.7 nM。HDAC6-IN-11 的选择性是其他 HDAC 异构体的 300 多倍。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | HDAC6-IN-11 (Compound 9) has anti-proliferative activities against cancer cells. HDAC6-IN-11 is a selective inhibitor of HDAC6 with the IC50 value of 20.7 nM. The selectivity of HDAC6-IN-11 is more than 300-fold over HDAC other isoforms [1]. |
体外活性 | HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells [1]. HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin [1]. Cell Proliferation Assay [1] Cell Line: A549 and HCT116 cells Concentration: 0.44-6.68 μM Incubation Time: 48 hours Result: Showed anti-proliferative activities to A549 and HCT116 cells (GI 50 =3.2 and 1.82 μM, respectively). Western Blot Analysis [1] Cell Line: HCT116 cells Concentration: 0, 0.6, 1.25, 2.5, 5, 10 and 20 μM Incubation Time: 48 hours Result: Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin. |
分子量 | 336.34 |
分子式 | C19H16N2O4 |
CAS No. | 2409072-27-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
HDAC6-IN-11 2409072-27-9 Inhibitor inhibitor inhibit