Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Geraniin 是一种肿瘤坏死因子α释放抑制剂,其IC50值为 43 μM,具有抗肿瘤、抗炎和抗高血糖活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 282 | 现货 | ||
5 mg | ¥ 822 | 现货 | ||
10 mg | ¥ 1,450 | 现货 | ||
25 mg | ¥ 2,450 | 现货 | ||
50 mg | ¥ 3,630 | 现货 | ||
100 mg | ¥ 5,170 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,520 | 现货 |
产品描述 | 1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo, is a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure. 4. Geraniin has anti-oxidant activity, induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death. 5. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. |
靶点活性 | TNF-α:43 μM. |
分子量 | 952.64 |
分子式 | C41H28O27 |
CAS No. | 60976-49-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: Soluble
Pyridine, Methanol, etc.: Soluble
DMSO: 91 mg/mL(95.5 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.0497 mL | 5.2486 mL | 10.4971 mL | 26.2429 mL |
5 mM | 0.2099 mL | 1.0497 mL | 2.0994 mL | 5.2486 mL | |
10 mM | 0.105 mL | 0.5249 mL | 1.0497 mL | 2.6243 mL | |
20 mM | 0.0525 mL | 0.2624 mL | 0.5249 mL | 1.3121 mL | |
50 mM | 0.021 mL | 0.105 mL | 0.2099 mL | 0.5249 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Geraniin 60976-49-0 Apoptosis oxidation-reduction Antioxidant TNF Tumor Necrosis Factor Receptor inhibit TNF Receptor Inhibitor TNFR inhibitor