keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fast Green FCF (FD&C Green No. 3) 是海绿色三芳基甲烷食用染料,最大吸收在625nm 处,将在电泳过程中的蛋白质染色,。
产品描述 | Fast Green FCF (FD&C Green No. 3), a safe biocompatible color additive, has been suggested to mitigate chronic pain. |
体内活性 | Pretreatment of Fast green FCF (100 mg/kg, i.p. daily for 7 days) alleviated depressive-like behavior in LPS-treated mice.?Fast green FCF suppressed the LPS-induced microglial and astrocyte activation in the hippocampus.?Fast green FCF decreased the mRNA and protein levels of Toll-like receptor 4 (TLR4) and Myeloid differentiation primary response 88 (Myd88) and suppressed the phosphorylation of nuclear factor-κB (NF-κB) in the hippocampus of LPS-treated mice.?Fast green FCF also downregulated hippocampal tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, but did not alter the level of the brain-derived neurotrophic factor (BDNF) in the hippocampus of LPS-treated mice.?The molecular docking simulation predicts that Fast green FCF may interact with TLR4 and interrupt the formation of the TLR4-MD2 complex[1]. |
别名 | C.I. 42053, 固绿 FCF, Food green 3, FD&C Green No. 3 |
分子量 | 808.85 |
分子式 | C37H34N2Na2O10S3 |
CAS No. | 2353-45-9 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/ml
H2O: 10 mg/mL (12.36 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 1.2363 mL | 6.1816 mL | 12.3632 mL | 30.9081 mL |
5 mM | 0.2473 mL | 1.2363 mL | 2.4726 mL | 6.1816 mL | |
10 mM | 0.1236 mL | 0.6182 mL | 1.2363 mL | 3.0908 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fast Green FCF 2353-45-9 Others C.I. 42053 Food green-3 固绿 FCF Food green 3 Inhibitor Food green3 inhibit FD&C Green No. 3 inhibitor