Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Epimagnolin A 是一种糠醛木脂素,具有中等的抗疟原虫活性,IC50值为5.7 μg/mL。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 728 | 现货 | ||
5 mg | ¥ 1,780 | 现货 | ||
10 mg | ¥ 2,690 | 现货 | ||
25 mg | ¥ 4,380 | 现货 | ||
50 mg | ¥ 6,190 | 现货 | ||
100 mg | ¥ 8,370 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,980 | 现货 |
产品描述 | Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion. |
体外活性 |
A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study.?it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.?Furthermore, it was investigated the modulating effects of epimagnolin A on mitogen-activated protein kinase, nuclear factor-kappa B (NF-κB), and activator protein 1 (AP-1) activities.?Phosphorylation of p38 and nuclear translocation of p50 and c-Jun were down-regulated by epimagnolin A in the PMA-stimulated THP-1 cell.?The results revealed that epimagnolin A attenuated the binding affinity of NF-κB and AP-1 transcription factors to IL-6 promoter and IL-6 production through p38/NF-kB and AP-1 signaling pathways in the PMA-stimulated THP-1 cells.?These results suggest that epimagnolin A can be a useful drug for the treatment of inflammatory diseases[2]. |
分子量 | 416.46 |
分子式 | C23H28O7 |
CAS No. | 41689-51-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (28.81 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4012 mL | 12.006 mL | 24.0119 mL | 60.0298 mL |
5 mM | 0.4802 mL | 2.4012 mL | 4.8024 mL | 12.006 mL | |
10 mM | 0.2401 mL | 1.2006 mL | 2.4012 mL | 6.003 mL | |
20 mM | 0.1201 mL | 0.6003 mL | 1.2006 mL | 3.0015 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Epimagnolin A 41689-51-4 Microbiology/Virology Parasite furfuran inhibit Inhibitor lignan antiplasmodial inhibitor