Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Epiberberine chloride (Epiberberine (chloride)) 是一种从黄连中得到的生物碱,是一种AChE 和BChE 抑制剂,和非竞争性的BACE1抑制剂。它具有抗氧化作用,能够清除 ONOO-,可用于研究阿尔滋海默症和糖尿病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 447 | 5日内发货 | ||
5 mg | ¥ 814 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 822 | 5日内发货 |
Epiberberine chloride 的其他形式现货产品:
产品描述 | Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM). |
靶点活性 | BACE1:8.55 μM, BChE:6.03 µM, AChE:1.07 µM |
体外活性 | Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3]. |
体内活性 | Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days). |
别名 | 表小檗碱氯化物, Epiberberine (chloride), 盐酸表小檗碱 |
分子量 | 371.8 |
分子式 | C20H18ClNO4 |
CAS No. | 889665-86-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.4 mg/mL (19.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6896 mL | 13.4481 mL | 26.8962 mL | 67.2405 mL |
5 mM | 0.5379 mL | 2.6896 mL | 5.3792 mL | 13.4481 mL | |
10 mM | 0.269 mL | 1.3448 mL | 2.6896 mL | 6.724 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Epiberberine chloride 889665-86-5 Immunology/Inflammation Metabolism Neuroscience NF-Κb AChE AChR BACE Reactive Oxygen Species Beta-Secretase Epiberberine 表小檗碱氯化物 Epiberberine (chloride) Cholinesterase (ChE) inhibit β-Secretase Epiberberine Chloride Inhibitor Beta-secretase 盐酸表小檗碱 inhibitor