Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ensaculin (Anseculin) 是一种用哌嗪部分取代的新型苯并吡喃酮,在正常和人工遗忘啮齿动物的被动和条件回避范式中显示出记忆增强作用。它在NMDA 毒性模型中表现出神经保护活性,在原代培养的大鼠脑细胞中表现出神经营养作用。Ensaculin 可用于治疗痴呆。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 900 | 现货 | ||
5 mg | ¥ 2,210 | 现货 | ||
10 mg | ¥ 3,310 | 现货 | ||
25 mg | ¥ 5,380 | 现货 | ||
50 mg | ¥ 7,580 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,800 | 现货 |
产品描述 | Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia. |
靶点活性 | D2:16.6 nM, D3:27.7 nM, D4:277 nM, α1A:4.7 nM, α1B:9.3 nM, α:>100 nM, 5-HT1A:8 nM, 5-HT2:>100 nM |
体内活性 | Ensaculin (0.1, 1 and 10 mg/kg; i.p.; Wistar rats; 20 min after the onset of glutamate perfusion) significantly antagonized the formation of 2,3-DHBA, to values of 60.5% and 56.7% of control levels, respectively. Ensaculin may be useful in the treatment of neurodegenerative disorders associated with elevated hydroxyl free radicals and excitotoxicity.[1] |
别名 | Anseculin |
分子量 | 452.54 |
分子式 | C26H32N2O5 |
CAS No. | 155773-59-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.6 mg/mL (94.03 mM ), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2097 mL | 11.0487 mL | 22.0975 mL | 55.2437 mL |
5 mM | 0.4419 mL | 2.2097 mL | 4.4195 mL | 11.0487 mL | |
10 mM | 0.221 mL | 1.1049 mL | 2.2097 mL | 5.5244 mL | |
20 mM | 0.1105 mL | 0.5524 mL | 1.1049 mL | 2.7622 mL | |
50 mM | 0.0442 mL | 0.221 mL | 0.4419 mL | 1.1049 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ensaculin 155773-59-4 Anseculin Inhibitor inhibitor inhibit