Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Domperidone (R33812) 是多巴胺 2 受体拮抗剂,能够影响胃和小肠的化学感受器触发区和运动功能,具有止吐和促动力作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 184 | 现货 | ||
100 mg | ¥ 331 | 现货 | ||
200 mg | ¥ 596 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 385 | 现货 |
产品描述 | Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa). |
体外活性 | Domperidone (a D2R antagonist) inhibits Equilibrative NT1 (ENT1) activity more in the presence than in the absence of Bromocriptine and displays an IC50 value lower than that of Bromocriptine or Ergovaline in Madin-Darby bovine kidney (MDBK) cells. [1] |
体内活性 | Domperidone (0.1 mg/kg) results in a significant decrease in feeding behavior and stimulation of basal metabolism, but has no effect on locomotor activity of rats in a Phenomaster system. [2] Domperidone (1.1 mg/kg and 5.5 mg/kg, oral) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, beginning 4 hours after administration, and this effect persisted for at least 8 hours. Domperidone (0.2 mg/kg, i.v.) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, at 10 and 12 hours after administration. [3] Domperidone can ameliorate deleterious reproductive effects and reduce weight gain associated with fescue toxicosis in heifers. [4] Domperidone-treated mares have shorter gestation duration and foaled closer to their expected parturition date than did control mares. Domperidone-treated mares have higher Mammary gland scores and serum prolactin concentration. [5] Domperidone (5 mg/kg, oral) increases peak plasma acetaminophen concentration and area under the curve in rats, indicating increased gastric emptying. Domperidone decreases the dopamine-induced contractile activity of midjejunal longitudinal muscle strips in rats. [6] |
别名 | R33812, 多潘立酮 |
分子量 | 425.91 |
分子式 | C22H24ClN5O2 |
CAS No. | 57808-66-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.6 mg/mL (100 mM)
1eq. HCl: 2.1 mg/mL (5 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / 1eq. HCl | 1 mM | 2.3479 mL | 11.7396 mL | 23.4791 mL | 58.6978 mL |
5 mM | 0.4696 mL | 2.3479 mL | 4.6958 mL | 11.7396 mL | |
DMSO | 10 mM | 0.2348 mL | 1.174 mL | 2.3479 mL | 5.8698 mL |
20 mM | 0.1174 mL | 0.587 mL | 1.174 mL | 2.9349 mL | |
50 mM | 0.047 mL | 0.2348 mL | 0.4696 mL | 1.174 mL | |
100 mM | 0.0235 mL | 0.1174 mL | 0.2348 mL | 0.587 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Domperidone 57808-66-9 GPCR/G Protein Neuroscience Dopamine Receptor dopamine antiemetic symptoms nausea oral neurological R 33812 blood-brain barrier adverse inhibit R33812 多潘立酮 prokinetic vomit Inhibitor R-33812 inhibitor