Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diclofenac Potassium (CGP-45840B) 是一种非甾体抗炎药,用于减轻炎症并在某些情况下作为镇痛剂减轻疼痛。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。它是一种COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM 和0.84 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 248 | 现货 | ||
25 mg | ¥ 398 | 现货 | ||
50 mg | ¥ 578 | 现货 | ||
100 mg | ¥ 828 | 现货 | ||
200 mg | ¥ 1,260 | 现货 | ||
500 mg | ¥ 2,290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 287 | 现货 |
产品描述 | Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
靶点活性 | COX-2(human):1.3 nM (IC50, in CHO cells), COX-1 (ovine):5.1 nM (IC50), COX-1 (ovine):0.84 nM (IC50), COX-1 (human):4 nM (IC50, in CHO cells) |
体外活性 | The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. |
别名 | 双氯芬酸钾, CGP-45840B, Cataflam, Voltfast |
分子量 | 334.24 |
分子式 | C14H10Cl2KNO2 |
CAS No. | 15307-81-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL (29.91 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (164.55 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.9919 mL | 14.9593 mL | 29.9186 mL | 74.7966 mL |
5 mM | 0.5984 mL | 2.9919 mL | 5.9837 mL | 14.9593 mL | |
10 mM | 0.2992 mL | 1.4959 mL | 2.9919 mL | 7.4797 mL | |
20 mM | 0.1496 mL | 0.748 mL | 1.4959 mL | 3.7398 mL | |
DMSO | 50 mM | 0.0598 mL | 0.2992 mL | 0.5984 mL | 1.4959 mL |
100 mM | 0.0299 mL | 0.1496 mL | 0.2992 mL | 0.748 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Diclofenac Potassium 15307-81-0 Apoptosis Immunology/Inflammation Neuroscience Others COX 双氯芬酸钾 CHO CGP-45840B caspase COX-1 cascade anti-inflammatory neural cells stem ovine NSCs Diclofenac Inhibitor Cataflam inhibit Voltfast Cyclooxygenase COX-2 inhibitor