Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂,能够作用于糖皮质激素受体。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
200 mg | ¥ 172 | 现货 | ||
500 mg | ¥ 249 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 91 | 现货 |
产品描述 | Desonide (Prednacinolone) is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release of arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. |
别名 | Tridesilon, 地索奈德, Locapred, Prednacinolone |
分子量 | 416.51 |
分子式 | C24H32O6 |
CAS No. | 638-94-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 28 mg/mL (67.2 mM)
DMSO: 55 mg/mL (132.05 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 2.4009 mL | 12.0045 mL | 24.009 mL | 60.0226 mL |
5 mM | 0.4802 mL | 2.4009 mL | 4.8018 mL | 12.0045 mL | |
10 mM | 0.2401 mL | 1.2005 mL | 2.4009 mL | 6.0023 mL | |
20 mM | 0.12 mL | 0.6002 mL | 1.2005 mL | 3.0011 mL | |
50 mM | 0.048 mL | 0.2401 mL | 0.4802 mL | 1.2005 mL | |
DMSO | 100 mM | 0.024 mL | 0.12 mL | 0.2401 mL | 0.6002 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Desonide 638-94-8 Endocrinology/Hormones Glucocorticoid Receptor Tridesilon inhibit 地索奈德 Locapred Inhibitor Prednacinolone inhibitor