Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Desisobutyryl-ciclesonide has an affinity for glucocorticoid receptors. Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 452 | 5日内发货 | ||
100 mg | ¥ 7,840 | 6-8周 |
产品描述 | Desisobutyryl-ciclesonide has an affinity for glucocorticoid receptors. Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. |
体外活性 | Ciclesonide is an inhaled glucocorticoid with little affinity for glucocorticoid receptors. When converted into an active metabolite Desisobutyryl-ciclesonide, it is very effective in down-regulating the proinflammatory activity of airway parenchymal cells in vitro. 0.3-3.0μMCiclesonide and Desisobutyryl-Ciclesonide dose-dependently inhibited the proliferation of peripheral blood mononuclear cells to Candida albicans, but Desisobutyryl-Ciclesonide had a higher inhibitory effect. Significant proliferation of PhlP5 was observed only in cultures of ectopic subjects: effective downregulation has been detected at 0.03 μM Ciclesonide and 0.003 μM Desisobutyryl-Ciclesonide (at 3 μM Ciclesonide and 0.03 μM Desisobutyryl-ciclesonide Completely suppressed). 3μM Ciclesonide and Desisobutyryl-ciclesonide reduced the proportion of PhlP5-specific T cell embryonic cell proliferation and interleukin 4 producing cells. In PBMC cultures of atopic patients, both Csonide (CIC) and desisobutyryl-Crossonide (des-CIC) induced dose-dependent down-regulation of PhlP5-induced proliferation. At 0.03 μM Ciclesonide and 0.003 μM Desisobutyryl-Ciclesonide (p <0.001, each comparison), the effect is already significant (an earlier complete inhibition was observed at 3 μMCiclesonide and 0.03 μMDesisobutyryl-Ciclesonide. At 0.003 μM ( p<0.05), 0.03μM (p<0.001) and 0.3μM (p<0.05), the inhibitory activity of desisobutyryl-ciclesonide on PhlP5-induced PBMC proliferation was higher than that of Ciclesonide. |
别名 | CIC-AP, Ciclesonide active principle |
分子量 | 470.6 |
分子式 | C28H38O6 |
CAS No. | 161115-59-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (106.25 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1249 mL | 10.6247 mL | 21.2495 mL | 53.1237 mL |
5 mM | 0.425 mL | 2.1249 mL | 4.2499 mL | 10.6247 mL | |
10 mM | 0.2125 mL | 1.0625 mL | 2.1249 mL | 5.3124 mL | |
20 mM | 0.1062 mL | 0.5312 mL | 1.0625 mL | 2.6562 mL | |
50 mM | 0.0425 mL | 0.2125 mL | 0.425 mL | 1.0625 mL | |
100 mM | 0.0212 mL | 0.1062 mL | 0.2125 mL | 0.5312 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Desisobutyryl-ciclesonide 161115-59-9 Others Desisobutyryl ciclesonide CIC-AP Desisobutyrylciclesonide Ciclesonide active principle Inhibitor inhibitor inhibit