Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CyPPA 是hSK2和hSK3的阳性调节剂,其EC50值分别为 5.6 μM 和14 μM。它对 hSK1 和 hIK 通道无活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 233 | 现货 | ||
2 mg | ¥ 343 | 现货 | ||
5 mg | ¥ 577 | 现货 | ||
10 mg | ¥ 798 | 现货 | ||
25 mg | ¥ 1,750 | 现货 | ||
50 mg | ¥ 2,870 | 现货 | ||
100 mg | ¥ 4,260 | 现货 | ||
500 mg | ¥ 9,220 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 667 | 现货 |
产品描述 | CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization. |
靶点活性 | SK3:14 μM (EC50), SK2:5.6 μM (EC50) |
体外活性 | CyPPA, a positive modulator of SK2 and SK3, reduces the activity of dopaminergic neurons and inhibits dopamine release with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA counteracts hyperdopaminergic behaviors induced by methylphenidate. |
体内活性 | In vivo studies revealed that systemic administration of CyPPA attenuated methylphenidate-induced hyperactivity and stereotypic behaviors in mice. CyPPA induces a concentration-dependent increase in the apparent Ca2+ sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM |
分子量 | 285.39 |
分子式 | C16H23N5 |
CAS No. | 73029-73-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 99 mg/mL (346.89 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.504 mL | 17.5199 mL | 35.0398 mL | 87.5994 mL |
5 mM | 0.7008 mL | 3.504 mL | 7.008 mL | 17.5199 mL | |
10 mM | 0.3504 mL | 1.752 mL | 3.504 mL | 8.7599 mL | |
20 mM | 0.1752 mL | 0.876 mL | 1.752 mL | 4.38 mL | |
50 mM | 0.0701 mL | 0.3504 mL | 0.7008 mL | 1.752 mL | |
100 mM | 0.035 mL | 0.1752 mL | 0.3504 mL | 0.876 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CyPPA 73029-73-9 GPCR/G Protein Membrane transporter/Ion channel Neuroscience Potassium Channel Dopamine Receptor KcsA inhibit Inhibitor inhibitor