Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CXCR2-IN-1是可渗透中枢神经系统的 CXCR2拮抗剂,pIC50值为9.3。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 892 | 现货 | ||
5 mg | ¥ 2,320 | 现货 | ||
10 mg | ¥ 3,480 | 现货 | ||
25 mg | ¥ 5,630 | 现货 | ||
50 mg | ¥ 7,630 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,430 | 现货 |
产品描述 | CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent. |
靶点活性 | CXCR2:9.3(pIC50) |
体外活性 | CXCR2 plays an important role in the activation and recruitment of neutrophils to the site of inflammation. CXCR2-IN-1 showed good central nervous system penetration characteristics (Br / Bl> 0.45)[1]. |
体内活性 | CXCR2-IN-1 has shown efficacy in oral copper ketone-induced demyelination models by oral administration, providing evidence to support CXCR2 as a potential therapeutic target for the treatment of demyelinating diseases such as multiple sclerosis[1]. |
分子量 | 476.35 |
分子式 | C19H20Cl2FN3O4S |
CAS No. | 1873376-49-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.5 mg/mL (9.4 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0993 mL | 10.4965 mL | 20.993 mL | 52.4824 mL |
5 mM | 0.4199 mL | 2.0993 mL | 4.1986 mL | 10.4965 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CXCR2-IN-1 1873376-49-8 Autophagy GPCR/G Protein Immunology/Inflammation CXCR CXCR-2-IN-1 CXCR2 IN 1 CXCR2IN1 Inhibitor inhibitor inhibit