Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has < 1,000 fold selectivity over MMP1.
产品描述 | CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1. |
靶点活性 | MMP2:0.2 nM, MMP3:9.5 nM, MMP14:15 nM, MMP8:0.9 nM, MMP13:0.5 nM, MMP12:0.7 nM |
体内活性 | CTS-1027 improves overall animal survival following 14 days of BDL in mice [1]. CTS-1027 effectively reduces features of cholestatic liver injury, the hepatocyte apoptosis, and markers of hepatic fibrogenesis in the BDL mouse. The terminal plasma concentration of RS-130830 is 311 nM, in male animals treated for 8 weeks. RS-130830(8 weeks; male mice ) treatment causes an 89% increase in plasma triglyceride concentration. But there is no corresponding effect in female mice treated for 12 weeks. The plaque lipid content of animals receiving RS-130830 is increased by 81% at 12 weeks, and increased by 41% at 16 weeks [2]. |
别名 | RS 130830, Ro 1130830 |
分子量 | 425.88 |
分子式 | C19H20ClNO6S |
CAS No. | 193022-04-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (234.81 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3481 mL | 11.7404 mL | 23.4808 mL | 58.702 mL |
5 mM | 0.4696 mL | 2.3481 mL | 4.6962 mL | 11.7404 mL | |
10 mM | 0.2348 mL | 1.174 mL | 2.3481 mL | 5.8702 mL | |
20 mM | 0.1174 mL | 0.587 mL | 1.174 mL | 2.9351 mL | |
50 mM | 0.047 mL | 0.2348 mL | 0.4696 mL | 1.174 mL | |
100 mM | 0.0235 mL | 0.1174 mL | 0.2348 mL | 0.587 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CTS-1027 193022-04-7 Others RS 130830 Ro 1130830 RS130830 CTS1027 RS-130830 CTS 1027 Inhibitor inhibitor inhibit