keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Coumarin 6 (Coumarin VI) 是一种荧光染料,可作为微粒给药系统中的荧光探针,研究药物给药系统的体内跟踪、细胞摄取和转运机制。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 mg | ¥ 290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 250 | 现货 |
产品描述 | Coumarin 6 (Coumarin VI) is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro. |
体外活性 | We report the use of Coumarin 6(Coumarin VI) and 1,6-diphenyl-1,3,5-hexatriene (DPH) for the identification of protein aggregates for the first time. The two dyes can be used at very low (nanomolar) concentrations and do not interfere with the aggregation process, as is reported for other commonly used fluorescent protein probes. In the presence of protein aggregates, their quantum yields are significantly high. DPH is able to recognize both amorphous and fibrillar aggregates but cannot distinguish between them. Coumarin 6(Coumarin VI) can distinguish between both types of aggregates. It also exhibits the characteristic sigmoidal curve of amyloid formation, with higher sensitivity for detection of fibrillation than the conventionally used Thioflavin T. |
别名 | Coumarin VI, 香豆素 6 |
分子量 | 350.43 |
分子式 | C20H18N2O2S |
CAS No. | 38215-36-0 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (14.27 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8536 mL | 14.2682 mL | 28.5364 mL | 71.3409 mL |
5 mM | 0.5707 mL | 2.8536 mL | 5.7073 mL | 14.2682 mL | |
10 mM | 0.2854 mL | 1.4268 mL | 2.8536 mL | 7.1341 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Coumarin 6 38215-36-0 Others Coumarin6 Coumarin VI 香豆素 6 inhibit Coumarin-6 Inhibitor inhibitor