Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin inhibitor 11 是一种口服活性的有效微管蛋白抑制剂。它通过靶向秋水仙碱结合位点,抑制tubulin聚合,进而促进有丝分裂阻断和apoptosis。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 516 | 现货 | ||
5 mg | ¥ 1,190 | 现货 | ||
10 mg | ¥ 1,980 | 现货 | ||
25 mg | ¥ 3,370 | 现货 | ||
50 mg | ¥ 4,890 | 现货 | ||
100 mg | ¥ 6,860 | 现货 | ||
500 mg | ¥ 13,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,450 | 现货 |
产品描述 | Tubulin Inhibitor 11 is a potent, orally active agent that inhibits tubulin by targeting the Colchicine binding site. It impedes tubulin polymerization, leading to mitotic blockade and apoptosis. |
靶点活性 | Antiproliferative (DU145 cells):8 nM |
体外活性 |
Swainsonine (0-40 μM ; 12 h) showed anti-proliferative activity in U251 and LN444 cells.[2] Swainsonine (30 μM ; 12 h) induced apoptosis and cell cycle arrest in G2/M phase and decreased the expression of CyclinD1 and CDK4 protein levels and increased the expression of p16 protein level.[2] Swainsonine (30 μM ; 12 h) reduces glioma cell migration and invasion.[2] |
体内活性 | Swainsonine (1 mg/kg ; intraperitoneal injection ; twice daily for 10 days) and cisplatin increased the antitumor efficacy in mice.[3] |
分子量 | 409.5 |
分子式 | C22H23N3O3S |
CAS No. | 2366260-33-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (219.8 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.442 mL | 12.21 mL | 24.42 mL | 61.0501 mL |
5 mM | 0.4884 mL | 2.442 mL | 4.884 mL | 12.21 mL | |
10 mM | 0.2442 mL | 1.221 mL | 2.442 mL | 6.105 mL | |
20 mM | 0.1221 mL | 0.6105 mL | 1.221 mL | 3.0525 mL | |
50 mM | 0.0488 mL | 0.2442 mL | 0.4884 mL | 1.221 mL | |
100 mM | 0.0244 mL | 0.1221 mL | 0.2442 mL | 0.6105 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tubulin inhibitor 11 2366260-33-3 Apoptosis Cytoskeletal Signaling Microtubule Associated CompoundTubulininhibitor11 Inhibitor inhibitor inhibit