Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clopimozide (R-29764) 可作为一种钙通道拮抗剂,抑制 [3H] 尼群地平结合。Clopimozide 是一种新型且可口服的长效抗精神分裂症精神安定化合物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,010 | 现货 | ||
5 mg | ¥ 2,490 | 现货 | ||
10 mg | ¥ 3,720 | 现货 | ||
25 mg | ¥ 5,990 | 现货 | ||
50 mg | ¥ 8,290 | 现货 | ||
100 mg | ¥ 10,900 | 现货 | ||
500 mg | ¥ 22,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,930 | 现货 |
产品描述 | Clopimozide (R-29764) acts as a calcium channel antagonist and inhibits [3H] nilandipine binding.Clopimozide is a novel and orally available long-acting antischizophrenic psychostatic compound. |
靶点活性 | D2 receptor:0.01 µM, α1-adrenoceptor:0.25 µM, Ca2+ channel:0.017 µM |
体内活性 | Clopimozide (5 and 35 mg) in 10 patients' plasma levels were determined with the radio-immunological method. The product exhibited a marked effect on schizophrenic target symptoms (significant at the 0.001 and 0.01 levels), of at least one week's duration, with an absence of sedation and a low degree of extrapyramidal side effects. Clopimozide appears to be particularly suitable for the neuroleptic long-term treatment of compensated schizophrenic patients with insight into their disease.[3] |
别名 | R-29764, NSC-335305, NSC 335305, NSC335305, R 29764 |
分子量 | 495.99 |
分子式 | C28H28ClF2N3O |
CAS No. | 53179-12-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.96 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0162 mL | 10.0808 mL | 20.1617 mL | 50.4042 mL |
5 mM | 0.4032 mL | 2.0162 mL | 4.0323 mL | 10.0808 mL | |
10 mM | 0.2016 mL | 1.0081 mL | 2.0162 mL | 5.0404 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Clopimozide 53179-12-7 Membrane transporter/Ion channel Metabolism Calcium Channel R-29764 NSC-335305 NSC 335305 R29764 NSC335305 R 29764 Inhibitor inhibitor inhibit