Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clindamycin (Sobelin) 从细菌核糖体中解离肽基-tRNA,破坏细菌蛋白质合成。 它是一种半合成广谱抗生素,由母体化合物林可霉素化学修饰而成。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 249 | 现货 | ||
25 mg | ¥ 418 | 现货 | ||
50 mg | ¥ 595 | 现货 | ||
100 mg | ¥ 866 | 现货 |
产品描述 | Clindamycin (Sobelin) dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. Clindamycin is a semisynthetic broad-spectrum antibiotic produced by chemical modification of the parent compound lincomycin. |
体外活性 | Clindamycin is a semisynthetic analogue of lincomycin. Clindamycin primarily inhibits the initiation of peptide chain synthesis by deregulating enzyme-catalyzed initiation of peptide bounds. Clindamycin appears to have a modest effect on protein synthesis by certain mammalian cells. [1] Clindamycin is active against most gram-positive aerobic bacteria. Clindamycin is about eight times more active than lincomycin against Staphylococcus aureus and Streptococcus pneumonia. Clindamycin is four times more active than erythromycin against S. aureus and is active even against strains that are resistant to erythromycin, penicillin, and methicillin. Clindamycin is active against gram-positive anaerobes. Clindamycin highly activates against Bacteroides specie. [2] Clindamyci also alters the bacterial surface in such a way that phagocytosis and intracellular killing of the bacteria is greatly facilitated. Clindamycin potentiates opsonization and phagocytosis. [4] |
体内活性 | Clindamycin (50 mg/kg daily administrated by intramuscular) increases the survival rate of monkeys infected with penicillin-resistant S. aureu to 87.5% (7/8). [5] Clindamycin (40 mg/kg administrated three times daily) protects 87.5% (7/8) of rabbits from anaerobic pulmonary infections induced by transtracheal inoculation of a mixture of B. fragillis, Streptococcus morbillorm, Fusobacterium nucleatum and Eubacterium lentum. [6] Clindamycin (400 mg/kg treated by mixed in the diet) increases survival rate of mice infected with the Toxoplasma gondii to 100%, while all animals die in untreated group. [7] |
别名 | Clinimycin, Sobelin, Chlolincocin, 克林霉素 |
分子量 | 424.98 |
分子式 | C18H33ClN2O5S |
CAS No. | 18323-44-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 79 mg/mL (185.9 mM)
Ethanol: 79 mg/mL (185.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 2.3531 mL | 11.7653 mL | 23.5305 mL | 58.8263 mL |
5 mM | 0.4706 mL | 2.3531 mL | 4.7061 mL | 11.7653 mL | |
10 mM | 0.2353 mL | 1.1765 mL | 2.3531 mL | 5.8826 mL | |
20 mM | 0.1177 mL | 0.5883 mL | 1.1765 mL | 2.9413 mL | |
50 mM | 0.0471 mL | 0.2353 mL | 0.4706 mL | 1.1765 mL | |
100 mM | 0.0235 mL | 0.1177 mL | 0.2353 mL | 0.5883 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Clindamycin 18323-44-9 Microbiology/Virology Antibacterial Antibiotic broad-spectrum Clinimycin Sobelin Parasite Inhibitor inhibit Chlolincocin bacteriostatic Bacterial lincosamide 克林霉素 malaria inhibitor