Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 198 | 现货 | ||
10 mg | ¥ 372 | 现货 | ||
25 mg | ¥ 567 | 现货 | ||
50 mg | ¥ 747 | 现货 | ||
100 mg | ¥ 1,160 | 现货 | ||
200 mg | ¥ 1,720 | 现货 |
产品描述 | Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis. |
体外活性 | Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3] |
体内活性 | Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5] |
激酶实验 | EGFR kinase assays: In vitro inhibitory enzyme kinetic assays using recombinant EGFR L858R/T790M and WT protein and are performed using the ATP/NADH coupled assay system in a 96-well format. WZ4002 is added to determine its inhibitory effects. |
别名 | HPMPC, GS 0504, 西多福韦, (S)-HPMPC |
分子量 | 279.19 |
分子式 | C8H14N3O6P |
CAS No. | 113852-37-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 5 mg/mL (17.91 mM), Sonication is recommended.
DMSO: < 1 mg/mL (insoluble or slightly soluble) (3.58 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 3.5818 mL | 17.909 mL | 35.8179 mL | 89.5448 mL |
H2O | 5 mM | 0.7164 mL | 3.5818 mL | 7.1636 mL | 17.909 mL |
10 mM | 0.3582 mL | 1.7909 mL | 3.5818 mL | 8.9545 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cidofovir 113852-37-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Others DNA/RNA Synthesis Inhibitor HPMPC Endogenous Metabolite Apoptosis GS 0504 inhibit cancer retinitis GS-0504 antiviral GS0504 CMV 西多福韦 (S)-HPMPC Orthopoxvirus Cytomegalovirus herpes inhibitor