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Celgosivir hydrochloride

产品编号 T10755 CAS 141117-12-6

别名: MX3253 hydrochloride, MBI 3253 hydrochloride, MDL 28574 hydrochloride

Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM).

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Celgosivir hydrochloride Chemical Structure

Celgosivir hydrochloride, CAS 141117-12-6

规格	价格/CNY	货期
2 mg	￥ 1,820	5日内发货
5 mg	￥ 3,320	5日内发货
25 mg	￥ 11,600	8-10周
50 mg	￥ 15,100	8-10周
100 mg	￥ 21,500	8-10周
1 mL * 10 mM (in DMSO)	￥ 3,970	5日内发货

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Celgosivir hydrochloride 的其他形式现货产品:

Celgosivir

其他形式的 Celgosivir hydrochloride:

Celgosivir
现货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM).
靶点活性	α-glucosidase I:1.27 μM
体外活性	Celgosivir is more effective (IC50: 20 μM) than the parent molecule (IC50: 254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 (IC50: 2.0 μM) [1]. BVDV is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively [2]. Celgosivir inhibits DENV2 replication with an EC50 of 0.2 μM. The EC50 values against DENV1, 3, and 4 are less than 0.7 μM [3].
体内活性	During primary infection with a mouse-adapted DENV strain S221, mice show increased viremia on day 3, yet 80% survived day 10 with a virus completely cleared by day 8 [3]. Celgosivir (50 mg/kg, BID for 5 days) fully protects AG129 mice from lethal infection with a mouse-adapted dengue virus and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25, or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice show that it rapidly metabolizes to castanospermine [4].

别名	MX3253 hydrochloride, MBI 3253 hydrochloride, MDL 28574 hydrochloride
分子量	295.76
分子式	C12H22ClNO5
CAS No.	141117-12-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 100 mg/mL (338.11 mM)

DMSO: 100 mg/mL (338.11 mM), Sonication is recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
H2O / DMSO	1 mM	3.3811 mL	16.9056 mL	33.8112 mL	84.528 mL
	5 mM	0.6762 mL	3.3811 mL	6.7622 mL	16.9056 mL
	10 mM	0.3381 mL	1.6906 mL	3.3811 mL	8.4528 mL
	20 mM	0.1691 mL	0.8453 mL	1.6906 mL	4.2264 mL
	50 mM	0.0676 mL	0.3381 mL	0.6762 mL	1.6906 mL
	100 mM	0.0338 mL	0.1691 mL	0.3381 mL	0.8453 mL

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参考文献

1. Taylor DL, et al. Inhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoylcastanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cells. Antimicrob Agents Chemother. 1994 Aug;38(8):1780-7. 2. Whitby K, et al. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Antivir Chem Chemother. 2004 May;15(3):141-51. 3. Watanabe S, et al. Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial. Antiviral Res. 2012 Oct;96(1):32-5. 4. Rathore AP, et al. Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes andprotects against lethal challenge mouse model. Antiviral Res. 2011 Dec;92(3):453-60.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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