Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCG-50014 是一种有效的选择性 RGS4 抑制剂,IC50 为 30 nM。它在小鼠福尔马林试验中减少伤害性反应并增强阿片类药物介导减缓疼痛的作用。它与 RGS 共价结合,在位于变构调节位点的两个半胱氨酸残基上形成加合物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 267 | 现货 | ||
2 mg | ¥ 379 | 现货 | ||
5 mg | ¥ 618 | 现货 | ||
10 mg | ¥ 996 | 现货 | ||
25 mg | ¥ 1,990 | 现货 | ||
50 mg | ¥ 3,390 | 现货 | ||
100 mg | ¥ 4,970 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 687 | 现货 |
产品描述 | CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM. |
靶点活性 | RGS4:30 nM |
体外活性 | CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys?). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4?Gαo protein?protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. [1] [2] |
别名 | CCG 50014, 4-[(4-氟苯基)甲基]-2-(4-甲基苯基)-1,2,4-噻二唑烷-3,5-二酮 |
分子量 | 316.35 |
分子式 | C16H13FN2O2S |
CAS No. | 883050-24-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 59 mg/mL (186.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1611 mL | 15.8053 mL | 31.6106 mL | 79.0264 mL |
5 mM | 0.6322 mL | 3.1611 mL | 6.3221 mL | 15.8053 mL | |
10 mM | 0.3161 mL | 1.5805 mL | 3.1611 mL | 7.9026 mL | |
20 mM | 0.1581 mL | 0.7903 mL | 1.5805 mL | 3.9513 mL | |
50 mM | 0.0632 mL | 0.3161 mL | 0.6322 mL | 1.5805 mL | |
100 mM | 0.0316 mL | 0.1581 mL | 0.3161 mL | 0.7903 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CCG-50014 883050-24-6 GPCR/G Protein GTPase Regulators of G-protein Signaling Regulator of G-protein Signaling RGS Protein inhibit CCG 50014 4-[(4-氟苯基)甲基]-2-(4-甲基苯基)-1,2,4-噻二唑烷-3,5-二酮 Inhibitor CCG50014 inhibitor