Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) 是一种细胞渗透性 CBFβ 抑制剂,可抑制其与 Runx1 的结合。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 313 | 现货 | ||
2 mg | ¥ 443 | 现货 | ||
5 mg | ¥ 635 | 现货 | ||
10 mg | ¥ 1,180 | 现货 | ||
25 mg | ¥ 2,670 | 现货 | ||
50 mg | ¥ 3,690 | 现货 | ||
100 mg | ¥ 4,530 | 现货 | ||
200 mg | ¥ 6,810 | 现货 |
产品描述 | CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1. |
体外活性 | The ELISA results have shown that CBFβ Inhibitor is very effective in inhibiting the CBFβ-Runx1 interaction (IC50: 3.2 μM). In the leukemia cell line ME-1 expressing CBFβ-SMMHC, CBFβ Inhibitor reduced cell proliferation dose-dependently. Treatment with CBFβ Inhibitor for 3 days showed an increase in apoptotic cells. Treatment with CBFβ Inhibitor for 14 days individually or with all-trans-retinoic acid (ATRA) resulted in cells with greater variation in size and shape, lower nuclear-to-cytoplasmic ratio, increased folding, and lobation of nuclei, and more clumped chromatin. All of these morphology changes are consistent with differentiation to more mature forms. CBFβ Inhibitor at 50 μM increased proliferation of Hep-G2 cells. CBFβ treatment with Inhibitor resulted in a statistically significant reduction in Runx1 bound to DNA [1]. |
别名 | 5-乙基-4-(4-甲氧基苯基)-1,3-噻唑-2-胺, 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine |
分子量 | 234.32 |
分子式 | C12H14N2OS |
CAS No. | 493028-20-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 25 mg/mL
DMSO: 55 mg/mL (234.72 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.2677 mL | 21.3383 mL | 42.6767 mL | 106.6917 mL |
5 mM | 0.8535 mL | 4.2677 mL | 8.5353 mL | 21.3383 mL | |
10 mM | 0.4268 mL | 2.1338 mL | 4.2677 mL | 10.6692 mL | |
20 mM | 0.2134 mL | 1.0669 mL | 2.1338 mL | 5.3346 mL | |
50 mM | 0.0854 mL | 0.4268 mL | 0.8535 mL | 2.1338 mL | |
100 mM | 0.0427 mL | 0.2134 mL | 0.4268 mL | 1.0669 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CBFβ Inhibitor 493028-20-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis 5-乙基-4-(4-甲氧基苯基)-1,3-噻唑-2-胺 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine CBFbeta Inhibitor CBFb Inhibitor Inhibitor inhibitor inhibit