Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis,表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM,对K562细胞的IC50值为33.61 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | 待询 | 待询 | ||
50 mg | 待询 | 待询 |
产品描述 | Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively [1]. |
体外活性 | BX-2819 (0.001-10 μM, 16 h) inhibits the expression of ErbB2 protein and significantly enhances the expression of Hsp70 in HT-29, OVCAR3, and SKBR3 cells [1]. |
体内活性 | BX-2819 administered at 100 mg/kg intraperitoneally (i.p.) twice weekly substantially inhibited the expression of ErbB2 protein in NCI-N87 and SKOV3 tumor-bearing mice. Additionally, in HT-29 and NCI-N87 tumor models, it significantly reduced tumor growth and overall tumor burden [1]. A single dose of BX-2819 at 2 mg/kg given intravenously (i.v.) demonstrated a relatively short serum half-life (t1/2 = 0.8 h), high clearance (CL = 159 mL/min/kg), and a large volume of distribution (Vss = 4.5 L) in mice [1]. |
分子量 | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Caspase-3 activator 3 Apoptosis Proteases/Proteasome Caspase Inhibitor inhibitor inhibit