Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD7389 是一种 RSK 家族激酶抑制剂,对 RSK1、RSK2 和 RSK3 的 IC50 分别为 1.5 μM、2.4 μM 和 1.2 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 294 | 现货 | ||
5 mg | ¥ 539 | 现货 | ||
10 mg | ¥ 742 | 现货 | ||
25 mg | ¥ 1,183 | 现货 | ||
50 mg | ¥ 1,729 | 现货 | ||
100 mg | ¥ 2,548 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 637 | 现货 |
产品描述 | BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. |
靶点活性 | FLT3:3.5 μM, RSK3:1.2 μM, CDK5-p35:6.5 μM, Pim1:3.7 μM, DRAK1:2.8 μM, PKG1α:6.5 μM, SGK:13.8 μM, RSK2:2.4 μM, RSK1:1.5 μM |
体外活性 | BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation[1]. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[2]. |
分子量 | 366.41 |
分子式 | C24H18N2O2 |
CAS No. | 376382-11-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (54.58 mM), Sonification and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7292 mL | 13.6459 mL | 27.2918 mL | 68.2296 mL |
5 mM | 0.5458 mL | 2.7292 mL | 5.4584 mL | 13.6459 mL | |
10 mM | 0.2729 mL | 1.3646 mL | 2.7292 mL | 6.823 mL | |
20 mM | 0.1365 mL | 0.6823 mL | 1.3646 mL | 3.4115 mL | |
50 mM | 0.0546 mL | 0.2729 mL | 0.5458 mL | 1.3646 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
BRD7389 376382-11-5 Angiogenesis Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic JAK/STAT signaling MAPK Metabolism PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors CDK DAPK S6 Kinase FLT Pim SGK cancer S6K Inhibitor colon BRD 7389 inhibit RSK islets diabetes pancreatic SNU-407 BRD-7389 Ribosomal S6 Kinase (RSK) inhibitor