store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Uplarafenib (B-Raf IN 10) 是一种强效的 BRAF 抑制剂,其 IC50 在 50-100 nM 之间。B-Raf IN 10 具有抗肿瘤活性,可能不会影响细胞增殖和分化,可用于研究实体瘤。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 783 | 现货 | ||
5 mg | ¥ 1,930 | 现货 | ||
10 mg | ¥ 2,830 | 现货 | ||
25 mg | ¥ 5,990 | 现货 | ||
50 mg | ¥ 7,910 | 现货 | ||
100 mg | ¥ 10,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,130 | 现货 |
产品描述 | Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation and differentiation did not, and can be used to study solid tumors. |
体外活性 |
B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E [1]. B-Raf IN 10 shows an IC 50 between 50 and 100 nM against BRAF, and less than 50 nM against BRAF V600E.[1] B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cell growth but not CHL-1 and SK-MEL-31 cells [1]. Cell Viability Assay.[1] Cell Line: A375, SK-MEL-28, SK-MEL-31, and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31. |
别名 | B-Raf IN 10 |
分子量 | 494.49 |
分子式 | C22H21F3N4O4S |
CAS No. | 1425485-87-5 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (182.00 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0223 mL | 10.1114 mL | 20.2229 mL | 50.5571 mL |
5 mM | 0.4045 mL | 2.0223 mL | 4.0446 mL | 10.1114 mL | |
10 mM | 0.2022 mL | 1.0111 mL | 2.0223 mL | 5.0557 mL | |
20 mM | 0.1011 mL | 0.5056 mL | 1.0111 mL | 2.5279 mL | |
50 mM | 0.0404 mL | 0.2022 mL | 0.4045 mL | 1.0111 mL | |
100 mM | 0.0202 mL | 0.1011 mL | 0.2022 mL | 0.5056 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Uplarafenib 1425485-87-5 MAPK Raf B-Raf IN 10 Inhibitor inhibitor inhibit