store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD-9574 是 SSB 位点的 PARP1 特异性抑制剂。 AZD-9574 具有抗癌活性,可用于 HRD+ 乳腺癌和晚期实体恶性肿瘤的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,090 | 现货 | ||
5 mg | ¥ 2,650 | 现货 | ||
10 mg | ¥ 3,980 | 现货 | ||
25 mg | ¥ 7,160 | 现货 | ||
50 mg | ¥ 9,660 | 现货 | ||
100 mg | ¥ 12,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,920 | 现货 |
产品描述 | AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies. |
体外活性 | AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6[1]. |
体内活性 | In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice[1]. |
分子量 | 428.44 |
分子式 | C21H22F2N6O2 |
CAS No. | 2756333-39-6 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL (18.67 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.334 mL | 11.6702 mL | 23.3405 mL | 58.3512 mL |
5 mM | 0.4668 mL | 2.334 mL | 4.6681 mL | 11.6702 mL | |
10 mM | 0.2334 mL | 1.167 mL | 2.334 mL | 5.8351 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AZD-9574 2756333-39-6 Chromatin/Epigenetic DNA Damage/DNA Repair PARP PPAR Peroxisome proliferator-activated receptors breast cancer inhibit HRR HRR-deficient cells homologous recombination repair AZD 9574 HRD+ AZD9574 Advanced Solid Malignancy Inhibitor aberrant DNA repair inhibitor