store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atomoxetine (HSDB 7352) 是一种选择性去甲肾上腺素抑制剂,它可能通过增加外周交感神经元中的去甲肾上腺素浓度而导致血压升高 。Atomoxetine 是突触前去 Norepinephrativev 转运体的高度选择性拮抗剂,对其他去甲肾上腺素受体或其他神经递质转运体或受体几乎或没有亲和力,但对5-羟色胺转运体的亲和力较弱。、 Atomoxetine 选择性地抑制去甲肾上腺素的再摄取,可用于治疗患有多动症和慢性抽搐的青少年。 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 Atomoxetine hydrochloride 的水溶性和稳定性通常比游离态更好。
产品描述 | Atomoxetine (HSDB 7352) is a selective norepinephrine inhibitor that may cause an increase in blood pressure by increasing norepinephrine concentrations in peripheral sympathetic neurons .Atomoxetine is a highly selective antagonist of presynaptic norepinephrine transporters with little or no affinity for other norepinephrine receptors or other neurotransmitter transporters or receptors, but has little or no affinity for 5- hydroxytryptamine transporter. Atomoxetine selectively inhibits reuptake of norepinephrine and can be used to treat adolescents with ADHD and chronic tics. |
靶点活性 | Norepinephrine:5 nM, 5-HT:77 nM, Dopamine:1451 nM |
体外活性 | Atomoxetine (Tomoxetine) exhibits state- and dose-dependent interaction with the human cardiac sodium channel (hNav1.5) in tsA201 cells, with concentrations ranging from 1 to 100 µM and exposure durations of 0.5 to 20 seconds.[2] |
体内活性 |
Administration of Atomoxetine (Tomoxetine) at doses of 0.3-3 mg/kg (i.p.) for a duration of 0-4 hours in male Sprague-Dawley rats results in a threefold increase in extracellular norepinephrine and dopamine levels, along with an increase in Fos expression observed in the prefrontal cortex.[1] Furthermore, Atomoxetine (Tomoxetine) at doses of 0.1-5 mg/kg (i.p. and p.o.) administered over a period of 14 days in spontaneously hypertensive rats demonstrates the potential to ameliorate ADHD-related behaviors in rats.[3] |
别名 | Tomoxetine, HSDB7352, HSDB-7352, HSDB 7352 |
分子量 | 255.35 |
分子式 | C17H21NO |
CAS No. | 83015-26-3 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Atomoxetine 83015-26-3 Neuroscience Norepinephrine Tomoxetine HSDB7352 HSDB-7352 HSDB 7352 Inhibitor inhibitor inhibit