Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ARN-21934 是高选择性的人拓扑异构酶 II α 抑制剂,具有血脑屏障通透性。依托泊苷抑制 DNA 松弛的IC50为120 μM,ARN-21934 抑制 DNA 松弛的IC50为 2 μM。ARN-21934具有良好的体内药代动力学特性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,160 | 现货 | ||
5 mg | ¥ 2,860 | 现货 | ||
10 mg | ¥ 4,230 | 现货 | ||
25 mg | ¥ 6,780 | 现货 | ||
50 mg | ¥ 9,180 | 现货 | ||
100 mg | ¥ 12,300 | 现货 | ||
500 mg | ¥ 24,800 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,950 | 现货 |
产品描述 | ARN-21934 is a potent and selective inhibitor for human topoisomerase II α and topoisomerase II β. ARN-21934(IC50 = 2 μM) inhibits DNA relaxation as compared to the anticancer agent Etoposide (IC50=120 μM). |
靶点活性 | Topo II:2 μM |
体外活性 | ARN-21934 is more potent against the α isoform. ARN-21934 exhibits a small panel of human cancer cell lines such as melanoma (A375, IC50 = 12.6 μM and G-361, IC50 = 8.1 μM), breast (MCF7, IC50 = 15.8 μM), endometrial (HeLa, IC50 = 38.2 μM), lung (A549, IC50 = 17.1 μM), and androgen-independent prostate (DU145, IC50 = 11.5 μM) cancer cells[1]. |
体内活性 | ARN-21934 is able to reach the brain, with a maximum concentration of compound at 60 min, and is still present in the brain 360 min after injection. ARN-21934 (intraperitoneal injection; 10 mg/kg) reaches a maximal plasma concentration of 0.68 μg/mL after 15 min. The half-life and clearance value are 149 min in circulation and 0.116 L/(min kg)[1]. |
分子量 | 360.46 |
分子式 | C21H24N6 |
CAS No. | 2230854-93-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8.33 mg/mL (23.11 mM), Sonication and heating to 80℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7742 mL | 13.8712 mL | 27.7423 mL | 69.3558 mL |
5 mM | 0.5548 mL | 2.7742 mL | 5.5485 mL | 13.8712 mL | |
10 mM | 0.2774 mL | 1.3871 mL | 2.7742 mL | 6.9356 mL | |
20 mM | 0.1387 mL | 0.6936 mL | 1.3871 mL | 3.4678 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ARN-21934 2230854-93-8 DNA Damage/DNA Repair Topoisomerase DNA relaxation Inhibitor anticancer topoisomerase IIα ARN21934 ARN 21934 inhibit inhibitor