alpha-Solanine

产品编号 TN1376   CAS 20562-02-1

Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.

alpha-Solanine , CAS 20562-02-1
规格 库存 价格/RMB 数量
1 mg 待询 2833.00
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纯度 98.00%
生物活性
化学信息
存储 & 溶解度
产品描述 Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
靶点活性 MMP,   PI3K,   Akt,  
体外活性 In this study, we inquired into the anti-carcinogenic effect of alpha-Solanine against human pancreatic cancer cells. We investigated the anti-carcinogenic effect of alpha-Solanine against human pancreatic cancer cells. In vitro, alpha-Solanine inhibited proliferation of PANC-1, sw1990, MIA PaCa-2 cells in a dose-dependent manner, as well as cell migration and invasion with atoxic doses. The expression of MMP-2/9, extracellular inducer of matrix metalloproteinase (EMMPRIN), CD44, eNOS and E-cadherin were suppressed by alpha-Solanine in PANC-1 cells. Moreover, significantly decreased vascular endothelial growth factor (VEGF) expression and tube formation of endothelial cells were discerned following alpha-Solanine treatment. Suppressed phosphorylation of Akt, mTOR, and Stat3, and strengthen phosphorylation of β-catenin was found, along with markedly decreased tran-nuclear of NF-κB, β-catenin and TCF-1. Following the administration of alpha-Solanine (6 µg/g for 2 weeks) in xenograft model, tumor volume and weight were decreased by 61% and 43% (p<0.05) respectively, showing decreased MMP-2/9, PCNA and VEGF expression.
别名
纯度 98.00%
分子量 868.06
分子式 C45H73NO15
CAS No. 20562-02-1

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文献引用

参考文献
1. Antitumor efficacy of α±-solanine against pancreatic cancer in vitro and in vivo.PLoS One. 2014 Feb 5;9(2):e87868.

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