keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alagebrium chloride (ALT711) 是晚期糖基化终产物(AGE) 抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
200 mg | ¥ 415 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 177 | 现货 |
产品描述 | Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic |
体内活性 | Alagebrium treatment in diabetic rats significantly inhibits neointimal hyperplasia after carotid balloon injury due to its inhibition of intracellular ROS synthesis, which results in inhibition of RASMCs proliferation[1]. |
动物实验 | Rat aortic vascular smooth muscle cells (RASMCs) were treated with 1-100 μM of alagebrium added 24 hours before the addition of AGEs.?This in vivo study was done using 8-week-old male rats that were injected intraperitoneally with 80 mg/kg STZ.?Sixteen weeks later, the diabetic rats were treated with 10 mg/kg alagebrium for 4 weeks, after which carotid artery balloon injury was induced.?After 4 weeks, the animals were sacrificed for histological analysis[1]. |
别名 | 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物, ALT711, 阿拉氯胺 |
分子量 | 267.77 |
分子式 | C13H14ClNOS |
CAS No. | 341028-37-3 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (93.36 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7345 mL | 18.6727 mL | 37.3455 mL | 93.3637 mL |
5 mM | 0.7469 mL | 3.7345 mL | 7.4691 mL | 18.6727 mL | |
10 mM | 0.3735 mL | 1.8673 mL | 3.7345 mL | 9.3364 mL | |
20 mM | 0.1867 mL | 0.9336 mL | 1.8673 mL | 4.6682 mL | |
50 mM | 0.0747 mL | 0.3735 mL | 0.7469 mL | 1.8673 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Alagebrium chloride 341028-37-3 Metabolism Others Endogenous Metabolite 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物 ALT711 阿拉氯胺 ALT-711 Inhibitor inhibit Alagebrium Alagebrium Chloride ALT 711 inhibitor