Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 397 | 现货 | ||
2 mg | ¥ 583 | 现货 | ||
5 mg | ¥ 996 | 现货 | ||
10 mg | ¥ 1,680 | 现货 | ||
25 mg | ¥ 3,390 | 现货 | ||
50 mg | ¥ 4,930 | 现货 | ||
100 mg | ¥ 6,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 875 | 现货 |
产品描述 | Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain. |
动物实验 | Brains of 4-mo-old C57BL/6 wild-type mice were dissected and mechanically disassociated in HBSS with a tissue homogenizer. Aliquots from each mouse were incubated with DMSO and two concentrations of Aftin-4 at 37°C for 3 h. Liquefied brains were sonicated and centrifuged at 13,000 rpm for 15 min. WB analysis was performed using CT695 antibody for soluble Aβ-CTF. They are for reference only. |
别名 | Aftin 4, Aftin4 |
分子量 | 368.48 |
分子式 | C20H28N6O |
CAS No. | 866893-90-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (149.26 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7139 mL | 13.5693 mL | 27.1385 mL | 67.8463 mL |
5 mM | 0.5428 mL | 2.7139 mL | 5.4277 mL | 13.5693 mL | |
10 mM | 0.2714 mL | 1.3569 mL | 2.7139 mL | 6.7846 mL | |
20 mM | 0.1357 mL | 0.6785 mL | 1.3569 mL | 3.3923 mL | |
50 mM | 0.0543 mL | 0.2714 mL | 0.5428 mL | 1.3569 mL | |
100 mM | 0.0271 mL | 0.1357 mL | 0.2714 mL | 0.6785 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Aftin-4 866893-90-5 Neuroscience Proteases/Proteasome Stem Cells Beta Amyloid Gamma-secretase Aftin 4 β-amyloid peptide inhibit Abeta Amyloid-β Aftin4 Inhibitor inhibitor