Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AC-262536 是非甾体雄激素受体选择性调节剂,具有有益的合成代谢作用。它可以强效激动雄激素受体,亲和力为1-10 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 263 | 现货 | ||
2 mg | ¥ 383 | 现货 | ||
5 mg | ¥ 645 | 现货 | ||
10 mg | ¥ 1,150 | 现货 | ||
25 mg | ¥ 2,490 | 现货 | ||
50 mg | ¥ 3,720 | 现货 | ||
100 mg | ¥ 5,350 | 现货 | ||
500 mg | ¥ 11,180 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 728 | 现货 |
产品描述 | AC-262536 is a selective androgen receptor (SAR) modulator and exhibits potent agonist activity at the androgen receptor. It has partial agonist activity with respect to testosterone and suppresses luteinizing hormone. |
体外活性 | AC-262536 inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP in a dose-dependent manner. The effects are significant with 100 nM, and reaches a plateau with 1 μM[2]. |
体内活性 | In male sprague-dawley rats, administration of AC-262536 (subcutaneous injection, once daily for 14 consecutive days) significantly decreased LH levels by about 40% at the 3 mg/kg dose. At the 10 and 30 mg/kg doses, the effects of AC-262536 were significantly stronger than Testosterone Propionate (TP) : 1.91±0.32 ng/mL and 1.53±0.34 ng/mL vs. 3.12±0.69 ng/mL, respectively[2]. |
别名 | AC262536, 4-(3-内型-羟基-8-氮杂双环[3.2.1]辛烷-8-基)萘-1-甲腈 |
分子量 | 278.35 |
分子式 | C18H18N2O |
CAS No. | 870888-46-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (179.63 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.5926 mL | 17.963 mL | 35.926 mL | 89.815 mL |
5 mM | 0.7185 mL | 3.5926 mL | 7.1852 mL | 17.963 mL | |
10 mM | 0.3593 mL | 1.7963 mL | 3.5926 mL | 8.9815 mL | |
20 mM | 0.1796 mL | 0.8981 mL | 1.7963 mL | 4.4907 mL | |
50 mM | 0.0719 mL | 0.3593 mL | 0.7185 mL | 1.7963 mL | |
100 mM | 0.0359 mL | 0.1796 mL | 0.3593 mL | 0.8981 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AC-262536 870888-46-3 Endocrinology/Hormones Androgen Receptor SARM AC 262536 modulator Inhibitor receptor AC262536 4-(3-内型-羟基-8-氮杂双环[3.2.1]辛烷-8-基)萘-1-甲腈 androgen anabolic inhibit non-steroidal inhibitor