Powder: -20°C for 3 years | In solvent: -80°C for 1 year
[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) 是一种高效的、内源性 apelin 受体选择性激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 627 | 现货 | ||
5 mg | ¥ 2,160 | 现货 | ||
10 mg | ¥ 3,490 | 现货 | ||
25 mg | ¥ 5,580 | 现货 | ||
50 mg | ¥ 7,580 | 现货 | ||
100 mg | ¥ 9,870 | 现货 |
产品描述 | [Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist. |
体外活性 | [Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release both in vitro and in vivo[1]. |
体内活性 | [Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold than SCI animals from the second week post SCI[2]. |
别名 | [pGlu1]-Apelin-13, 人牛吡啶APELIN-13 |
分子量 | 1533.8 |
分子式 | C69H108N22O16S |
CAS No. | 217082-60-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (32.60 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 0.652 mL | 3.2599 mL | 6.5198 mL | 16.2994 mL |
5 mM | 0.1304 mL | 0.652 mL | 1.304 mL | 3.2599 mL | |
10 mM | 0.0652 mL | 0.326 mL | 0.652 mL | 1.6299 mL | |
20 mM | 0.0326 mL | 0.163 mL | 0.326 mL | 0.815 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
[Pyr1]-Apelin-13 217082-60-5 GPCR/G Protein Apelin receptor inhibit [Pyr1]Apelin13 [pGlu1]-Apelin-13 人牛吡啶APELIN-13 [Pyr1] Apelin 13 Inhibitor [Pyr-1]-Apelin-13 inhibitor