store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zatosetron maleate(LY 277359 maleate) 是一种具有有效性和选择性的血清素 5HT3 受体拮抗剂,可用于研究急性偏头痛。
产品描述 | Zatosetron maleate(LY 277359 maleate) is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine. |
体内活性 | Acute administration of Zatosetron maleate (Zatosetron) at doses of 0.1 (n=21) and 0.3 (n=5) mg/kg in male rats, but not at doses of 0.01, 0.05, 1.0, or 10 mg/kg (n=5, 3, 6, and 4, respectively) Zatosetron maleate or saline (n=5), results in a significant reduction in the number of spontaneously active A10 dopamine cells. The number of spontaneously active A10 dopamine cells is not significantly different from 30 to 60 min post i.p. Zatosetron maleate (0.1 mg/kg) administration, shows a significant decrease by 60 to 90 min (0.65±0.11, P=0.03, n=5), a larger decrease by 90 to120 min (0.53±0.08, P=0.004, n=5), and remains at this significantly decreased level from 2 to 3 h (0.50+0.05, P=0.0004, n=5). Single-unit recordings demonstrate that Zatosetron maleate inhibits the activity of A10 dopamine cells following i.v. administration (ED50=0.12 mg/kg, n=8). Chronic administration of 0.1 mg/kg (n=16) Zatosetron maleate, but not 0.01, 1.0, or 10 mg/kg (n=4, 8, and 7, respectively) Zatosetron maleate or saline (n=5), leads to a significant reduction in the number of spontaneously active A10 dopamine cells[1]. |
别名 | LY 277359 maleate |
分子量 | 464.94 |
分子式 | C23H29ClN2O6 |
CAS No. | 123482-23-5 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Zatosetron maleate 123482-23-5 GPCR/G Protein Neuroscience 5-HT Receptor Zatosetron Maleate LY 277359 Maleate LY277359 Maleate LY 277359 maleate LY-277359 Maleate Inhibitor inhibitor inhibit