首页Chromatin/EpigeneticEpigenetic Reader DomainZL0420
ZL0420
编号 T6828    
CAS 2229039-45-4     分子式 C16H16N4O2     分子量 296.32
靶点: BRD4;
ZL0420 is a potent and selective BRD4 inhibitor. ZL0420 reduces airway inflammation and inhibits the TLR3-dependent innate immune gene program.
纯度:98.00%
规格 库存 单价 数量
2 mg 上海现货 418.00
5 mg 上海现货 597.00
10 mg 上海现货 1187.00
25 mg 上海现货 2087.00
50 mg 上海现货 3131.00
100 mg 上海现货 4696.00
200 mg 上海现货 6997.00
1 mL * 10 mM (in DMSO) 上海现货 687.00
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生物活性

产品描述

ZL0420 is a potent and selective BRD4 inhibitor. ZL0420 reduces airway inflammation and inhibits the TLR3-dependent innate immune gene program.

靶点活性

BRD4,

体外活性

体内活性

Potent efficacy reducing airway inflammation in a mouse model with low toxicity, indicating a proof of concept that BRD4 inhibitors may offer the therapeutic potential to block the viral-induced airway inflammation.

动物实验

Male C57BL6/J mice housed under pathogen-free conditions with food and water ad libitum.C57BL/6 mice were pre-treated in the absence or presence of the indicated BRD4 inhibitors [10 mg/kg body weight, via the intraperitoneal route] one day prior to poly stimulation.The next day, animals were given another dose of BRD4 inhibitor immediately followed by intranasal administration of phosphate-buffered saline (PBS, 50 μL) or poly (300 μg dissolved in 50 μL PBS).One day later, the mice were euthanized.The bronchoalveolar lavage fluid (BALF) and lung tissues of treated mice were collected for further analysis.Compounds were first dissolved in DMSO and further diluted in 10% hydroxypropyl β-cyclodextrin in PBS to appropriate concentration prior to intraperitoneal administration.

化学信息

分子量

296.32

分子式

C16H16N4O2

CAS

2229039-45-4

溶解度

DMSO: 59 mg/mL (199.11 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.375 ml 16.874 ml 33.747 ml
5 mM 0.675 ml 3.375 ml 6.749 ml
10 mM 0.337 ml 1.687 ml 3.375 ml
50 mM 0.067 ml 0.337 ml 0.675 ml
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