Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YUM70 是一种选择性葡萄糖调节蛋白 78 抑制剂,抑制全长蛋白的 GRP78 ATPase 活性的IC50值为 1.5 μM。它在胰腺癌中诱导内质网应激介导的细胞凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 547 | 现货 | ||
5 mg | ¥ 1,330 | 现货 | ||
10 mg | ¥ 1,950 | 现货 | ||
25 mg | ¥ 3,930 | 现货 | ||
50 mg | ¥ 5,630 | 现货 | ||
100 mg | ¥ 7,750 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,460 | 现货 |
产品描述 | YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. |
靶点活性 | GRP78:1.5 μM |
体外活性 | YUM70, inhibited pancreatic cancer cell growth in vitro.YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis.?A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER. |
体内活性 | YUM70 in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.YUM70 is a novel inducer of ER stress with preclinical efficacy as a monotherapy or in combination with topoisomerase and HDAC inhibitors in pancreatic cancer. |
分子量 | 398.84 |
分子式 | C21H19ClN2O4 |
CAS No. | 423145-35-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (250.73 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5073 mL | 12.5364 mL | 25.0727 mL | 62.6818 mL |
5 mM | 0.5015 mL | 2.5073 mL | 5.0145 mL | 12.5364 mL | |
10 mM | 0.2507 mL | 1.2536 mL | 2.5073 mL | 6.2682 mL | |
20 mM | 0.1254 mL | 0.6268 mL | 1.2536 mL | 3.1341 mL | |
50 mM | 0.0501 mL | 0.2507 mL | 0.5015 mL | 1.2536 mL | |
100 mM | 0.0251 mL | 0.1254 mL | 0.2507 mL | 0.6268 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
YUM70 423145-35-1 Apoptosis Cytoskeletal Signaling Endocrinology/Hormones GPCR/G Protein Metabolism GPR HSP Heat shock proteins cancer pancreatic reticulum YUM-70 GRP78 stress-mediated inhibit protein Inhibitor glucose-regulated endoplasmic YUM 70 inhibitor