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Y15

Y15

产品编号 T7119   CAS 4506-66-5
别名: 1,2,4,5-苯四胺四盐酸盐, 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14

Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) 是一种特异性的粘着斑激酶抑制剂,能够降低其自身磷酸化活性,抑制癌细胞的活力,阻断肿瘤生长。

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Y15 Chemical Structure
Y15, CAS 4506-66-5
规格 价格/CNY 货期 数量
5 mg ¥ 197 现货
10 mg ¥ 327 现货
25 mg ¥ 512 现货
50 mg ¥ 690 现货
100 mg ¥ 1,270 现货
200 mg ¥ 1,880 现货
500 mg ¥ 3,230 现货
1 mL * 10 mM (in DMSO) ¥ 229 现货
产品目录号及名称: Y15 (T7119)
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纯度: 98%
纯度: 98%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
体外活性 Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1].
细胞实验 Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour.
别名 1,2,4,5-苯四胺四盐酸盐, 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14
分子量 284.01
分子式 C6H14Cl4N4
CAS No. 4506-66-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 59 mg/mL (207.74 mM), sonification/heating is recommended.

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.521 mL 17.605 mL 35.21 mL 88.0251 mL
5 mM 0.7042 mL 3.521 mL 7.042 mL 17.605 mL
10 mM 0.3521 mL 1.7605 mL 3.521 mL 8.8025 mL
20 mM 0.1761 mL 0.8803 mL 1.7605 mL 4.4013 mL
50 mM 0.0704 mL 0.3521 mL 0.7042 mL 1.7605 mL
100 mM 0.0352 mL 0.1761 mL 0.3521 mL 0.8803 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. O'Brien S, Golubovskaya VM, Conroy J,et al.FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics[J].Oncotarget. 2014 Sep 15;5(17):7945-59. 2. Zheng D , Golubovskaya V , Kurenova E , et al. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts[J]. Molecular Carcinogenesis, 2010, 49(2):0-0. 3. Hochwald S N , Nyberg C , Zheng M , et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer[J]. Cell Cycle, 2009, 8(15):2435-2443.

文献引用

1. Sun Y, Qian Y, Chen C, et al. Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway. Journal of Experimental & Clinical Cancer Research. 2022, 41(1): 1-22 2. Hu S, Wang Z, Jin C, et al. Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair. Journal of Tissue Engineering. 2022, 13: 20417314221122123
NAMI-A FAK-IN-11 CEP-37440 AMP-945 Roslin 2 bromide Defactinib hydrochloride ALK inhibitor 1 BI-4464

相关化合物库

该产品包含在如下化合物库中:
抗癌活性化合物库 酪氨酸激酶分子库 血管生成库 NO PAINS 化合物库 激酶抑制剂库 抗癌化合物库 抑制剂库 细胞骨架化合物库 经典已知活性库 已知活性化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Y15 4506-66-5 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors FAK PTK2 protein tyrosine kinase 2 FAK Inhibitor-14 FAK Inhibitor14 Y-15 1,2,4,5-苯四胺四盐酸盐 PTK2 Focal adhesion kinase 1,2,4,5-Benzenetetramine tetrahydrochlor Y 15 Inhibitor FAK Inhibitor 14 inhibit FAK inhibitor Y15 inhibitor

 

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