Powder: -20°C for 3 years | In solvent: -80°C for 1 year
XCT790 是 ERRα的一种选择性反向激动剂,IC50值为 0.37 μM。它在化疗过程中诱导癌细胞死亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 198 | 现货 | ||
5 mg | ¥ 459 | 现货 | ||
10 mg | ¥ 856 | 现货 | ||
25 mg | ¥ 1,750 | 现货 | ||
50 mg | ¥ 3,410 | 现货 | ||
100 mg | ¥ 4,950 | 现货 | ||
500 mg | ¥ 9,870 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 612 | 现货 |
产品描述 | XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα). |
靶点活性 | ERRα:0.37 μM (IC50) |
激酶实验 | The inhibition of SHP2 from the tested compounds (SHP099) concentrations varying from 0.003-100 μM is monitored using an assay in which 0.5 nM of SHP2 is incubated with of 0.5 μM of peptide IRS1_pY1172(dPEG8)pY1222. After 30-60 minutes incubation at the surrogate substrate, DiFMUP is added to the reaction and incubated at 25 °C for 30 minutes. The reaction is then quenched by the addition of 5 μL of a 160 μM solution of bpV(Phen). The fluorescence signal is monitored using a microplate reader using excitation and emission wavelengths of 340 nm and 450 nm, respectively[1]. |
分子量 | 596.42 |
分子式 | C23H13F9N4O3S |
CAS No. | 725247-18-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 21 mg/mL (35.21 mM), Sonification and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6767 mL | 8.3834 mL | 16.7667 mL | 41.9168 mL |
5 mM | 0.3353 mL | 1.6767 mL | 3.3533 mL | 8.3834 mL | |
10 mM | 0.1677 mL | 0.8383 mL | 1.6767 mL | 4.1917 mL | |
20 mM | 0.0838 mL | 0.4192 mL | 0.8383 mL | 2.0958 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
XCT790 725247-18-7 Autophagy Endocrinology/Hormones Estrogen Receptor/ERR Estrogen/progestogen Receptor XCT 790 Inhibitor XCT-790 inhibit inhibitor